Open AccessSerum Cystatin C Is an Early Predictive Biomarker of Acute Kidney Injury after Pediatric Cardiopulmonary Bypass
Author(s) -
Catherine D. Krawczeski,
René G. VanDeVoorde,
Thelma Kathman,
Michael Bennett,
Jessica G. Woo,
Yu Wang,
Rachel E. Griffiths,
Prasad Devarajan
Publication year - 2010
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.02040310
Subject(s) - cystatin c , medicine , acute kidney injury , biomarker , creatinine , cardiopulmonary bypass , renal function , gastroenterology , urology , cardiology , biochemistry , chemistry
Acute kidney injury (AKI) is a frequent complication of cardiopulmonary bypass (CPB). Serum creatinine (SCr), the current standard, is an inadequate marker for AKI since a delay occurs before SCr rises. Biomarkers that are sensitive and rapidly measurable could allow early intervention and improve patient outcomes. We investigated the value of serum cystatin C as an early biomarker for AKI after pediatric CPB.