Elevated Subclinical Double-Stranded DNA Antibodies and Future Proliferative Lupus Nephritis
Author(s) -
Stephen W. Olson,
Jessica J. Lee,
Lisa K. Prince,
Thomas P. Baker,
Patricia J. Papadopoulos,
Jess D. Edison,
Kevin C. Abbott
Publication year - 2013
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.01910213
Subject(s) - medicine , antibody , lupus nephritis , anti dsdna antibodies , subclinical infection , gastroenterology , immunology , lupus erythematosus , disease
Elevated anti-double-stranded DNA (dsDNA) antibody and C-reactive protein are associated with proliferative lupus nephritis (PLN). Progression of quantitative anti-dsDNA antibody in patients with PLN has not been compared with that in patients with systemic lupus erythematosus (SLE) without LN before diagnosis. The temporal relationship between anti-dsDNA antibody and C-reactive protein elevation has also not been evaluated.
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