Symmetric Dimethylarginine as a Proinflammatory Agent in Chronic Kidney Disease | Zendy

Eva Schepers | Zendy; Daniela Veit Barreto | Zendy; Sophie Liabeuf | Zendy; Griet Glorieux | Zendy; Sunny Eloot | Zendy; Fellype Carvalho Barreto | Zendy; Ziad A. Massy | Zendy; Raymond Vanholder | Zendy

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Symmetric Dimethylarginine as a Proinflammatory Agent in Chronic Kidney Disease

Author(s) -

Eva Schepers,

Daniela Veit Barreto,

Sophie Liabeuf,

Griet Glorieux,

Sunny Eloot,

Fellype Carvalho Barreto,

Ziad A. Massy,

Raymond Vanholder

Publication year - 2011

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.01720211

Subject(s) - medicine , kidney disease , proinflammatory cytokine , renal function , inflammation , endocrinology , asymmetric dimethylarginine , tumor necrosis factor alpha , in vivo , arginine , chemistry , biology , biochemistry , amino acid , microbiology and biotechnology

Chronic kidney disease (CKD) is characterized by chronic inflammation, considered a nontraditional risk factor for cardiovascular disease, the major cause of death in CKD. Symmetric dimethylarginine (SDMA) was recently demonstrated to induce reactive oxygen species in monocytes. The present study further investigates the inflammatory character of SDMA compared with its structural counterpart asymmetric dimethylarginine (ADMA).

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