ADAMTS13 Secretion and Residual Activity among Patients with Congenital Thrombotic Thrombocytopenic Purpura with and without Renal Impairment | Zendy

Erica Rurali | Zendy; Federica Banterla | Zendy; Roberta Donadelli | Zendy; Elena Bresin | Zendy; Miriam Galbusera | Zendy; Sara Gastoldi | Zendy; Flora Peyvandi | Zendy; Mary Underwood | Zendy; Giuseppe Remuzzi | Zendy; Marioris | Zendy

Open Access

ADAMTS13 Secretion and Residual Activity among Patients with Congenital Thrombotic Thrombocytopenic Purpura with and without Renal Impairment

Author(s) -

Erica Rurali,

Federica Banterla,

Roberta Donadelli,

Elena Bresin,

Miriam Galbusera,

Sara Gastoldi,

Flora Peyvandi,

Mary Underwood,

Giuseppe Remuzzi,

Marioris

Publication year - 2015

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.01700215

Subject(s) - medicine , adamts13 , thrombotic thrombocytopenic purpura , odds ratio , gastroenterology , von willebrand factor , confidence interval , platelet , endocrinology

Acute renal impairment is observed in 11%-23% of patients with congenital thrombotic thrombocytopenic purpura (TTP) and deficiency of a disintegrin and metalloprotease with thrombospondin motifs 13 (ADAMTS13, a metalloprotease that cleaves von Willebrand factor [VWF] multimers), a substantial percentage of whom develop CKD during follow-up.

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