Sensitivity and Specificity of Pathologic Findings to Diagnose Lupus Nephritis | Zendy

Satoru Kudose | Zendy; Dominick Santoriello | Zendy; Andrew S. Bomback | Zendy; Michael B. Stokes | Zendy; Vivette D. D’Agati | Zendy; Glen S. Markowitz | Zendy

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Sensitivity and Specificity of Pathologic Findings to Diagnose Lupus Nephritis

Author(s) -

Satoru Kudose,

Dominick Santoriello,

Andrew S. Bomback,

Michael B. Stokes,

Vivette D. D’Agati,

Glen S. Markowitz

Publication year - 2019

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.01570219

Subject(s) - lupus nephritis , medicine , glomerulopathy , glomerulonephritis , systemic lupus erythematosus , pathology , nephritis , biopsy , renal biopsy , immunology , kidney , disease

In 2012, the Systemic Lupus International Collaborating Clinics proposed that lupus nephritis, in the presence of positive ANA or anti-dsDNA antibody, is sufficient to diagnose SLE. However, this "stand-alone" kidney biopsy criterion is problematic because the ISN/RPS classification does not specifically define lupus nephritis. We investigated the combination of pathologic features with optimal sensitivity and specificity for the diagnosis of lupus nephritis.

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