N-Acetylcysteine Effect on Serum Creatinine and Cystatin C Levels in CKD Patients | Zendy

Tariq Rehman | Zendy; Jason Fought | Zendy; Richard Solomon | Zendy

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N-Acetylcysteine Effect on Serum Creatinine and Cystatin C Levels in CKD Patients

Author(s) -

Tariq Rehman,

Jason Fought,

Richard Solomon

Publication year - 2008

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.01560408

Subject(s) - medicine , creatinine , cystatin c , renal function , acetylcysteine , kidney disease , contrast induced nephropathy , nephropathy , urology , confounding , population , gastroenterology , acute kidney injury , endocrinology , diabetes mellitus , biochemistry , chemistry , environmental health , antioxidant

N-acetylcysteine (NAC) has been widely used as a prophylactic therapy for contrast-induced nephropathy (CIN). Its efficacy is controversial because of heterogeneity in study results and because of evidence that NAC can alter serum creatinine levels without affecting glomerular filtration rate. This confounding effect of N-acetylcysteine on serum creatinine has not been rigorously tested, however, in a population at risk for CIN and following doses of NAC currently recommended for prophylaxis of CIN.

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