Open AccessDystroglycan in the Diagnosis of FSGS
Author(s) -
Giovanna A. Giannico,
Haichun Yang,
Eric G. Neilson,
Agnes B. Fogo
Publication year - 2009
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.01510209
Subject(s) - antigen , elispot , antibody , immune system , immunology , medicine , virology , cd8
alpha- and beta-dystroglycan (DG), which link the actin cytoskeleton of the podocyte to the glomerular basement membrane, are maintained in FSGS but decreased in minimal change disease (MCD). Fibrosis has been linked to increased fibroblast-specific protein-1 (FSP1) and epithelial-mesenchymal transition. We studied DG, FSP1, and podocyte differentiation in FSGS variants and cases of suspected FSGS.
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