HFE Mutations Modulate the Effect of Iron on Serum Hepcidin-25 in Chronic Hemodialysis Patients | Zendy

Luca Valenti | Zendy; Domenico Girelli | Zendy; Giovanni Valenti | Zendy; Annalisa Castagna | Zendy; Giovanna Como | Zendy; Natascia Campostrini | Zendy; Raffaela Rametta | Zendy; Paola Dongiovanni | Zendy; Piergiorgio Messa | Zendy; Silvia Fargion | Zendy

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HFE Mutations Modulate the Effect of Iron on Serum Hepcidin-25 in Chronic Hemodialysis Patients

Author(s) -

Luca Valenti,

Domenico Girelli,

Giovanni Valenti,

Annalisa Castagna,

Giovanna Como,

Natascia Campostrini,

Raffaela Rametta,

Paola Dongiovanni,

Piergiorgio Messa,

Silvia Fargion

Publication year - 2009

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.01370209

Subject(s) - hepcidin , medicine , hemodialysis , ferritin , anemia , transferrin saturation , endocrinology , gastroenterology , iron deficiency

Increased serum hepcidin has been reported in patients receiving chronic hemodialysis, and hypothesized to contribute to the alterations of iron metabolism of end-stage renal disease. However, no quantitative assessment is available to date; the clinical determinants are still under definition; and the role of genetic factors, namely HFE mutations, has not yet been evaluated. The aim of this study was to quantitatively assess serum hepcidin-25 in hemodialysis patients versus controls, and analyze the relationship between hepcidin, iron indices, HFE genotype, and erythropoietic parameters.

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