Length Polymorphism in Heme Oxygenase-1 and Cardiovascular Events and Mortality in Hemodialysis Patients | Zendy

Yu Hsin Chen | Zendy; S C Hung | Zendy; Der-Cherng Tarng | Zendy

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Length Polymorphism in Heme Oxygenase-1 and Cardiovascular Events and Mortality in Hemodialysis Patients

Author(s) -

Yu Hsin Chen,

S C Hung,

Der-Cherng Tarng

Publication year - 2013

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.01110113

Subject(s) - medicine , heme oxygenase , hemodialysis , heme , polymorphism (computer science) , cardiology , intensive care medicine , genotype , genetics , biochemistry , enzyme , gene , biology , chemistry

Persistent inflammation and oxidative stress play a pathogenic role in the high cardiovascular morbidity and mortality of hemodialysis patients. Heme oxygenase-1 is considered to have anti-inflammatory and antioxidant properties. This study assessed the association between the length of guanosine thymidine dinucleotide repeats in the heme oxygenase-1 gene microsatellite promoter and cardiovascular events and mortality among hemodialysis patients.

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