English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Background and objectives  Black Americans have a higher incidence of kidney disease compared with populations that do not have recent African ancestry. Two risk variants in the  APOL1  are responsible for a portion of this higher risk. We sought to assess the odds of AKI conferred by  APOL1  risk alleles in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.    Design, setting, participants, &amp; measurements  Black Americans who tested positive for coronavirus disease 2019 (COVID-19) were genotyped to determine  APOL1  risk allele status. We assessed the incidence of AKI, persistent AKI, and AKI requiring KRT within 21 days of the PCR-based diagnosis. Outcomes were adjusted for age, sex, body mass index, hypertension, eGFR, and use of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker.    Results  In total, 126 cases of SARS-CoV-2 infection were included within a 5-month period, with 16 (13%) and 110 (87%) cases with two and zero/one  APOL1  high-risk alleles, respectively. AKI occurred in 11 (69%) patients with two  APOL1  high-risk alleles and 39 (35%) patients with zero/one high-risk alleles (adjusted odds ratio, 4.41; 95% confidence interval, 1.11 to 17.52;  P =0.04). Persistent AKI occurred in eight (50%) patients with two  APOL1  high-risk alleles and 21 (19%) of those with zero/one high-risk alleles (adjusted odds ratio, 3.53; 95% confidence interval, 1.8 to 11.57;  P =0.04). AKI KRT occurred in four (25%) of those with two  APOL1  high-risk alleles and eight (7%) of those with zero/one high-risk alleles (adjusted odds ratio, 4.99; 95% confidence interval, 1.02 to 24.4,  P =0.05).    Conclusions   APOL1  high-risk alleles are associated with greater odds of AKI in Black American patients with COVID-19.

APOL1 Risk Variants and Acute Kidney Injury in Black Americans with COVID-19