A Case of Atypical Light Chain Deposition Disease—Diagnosis and Treatment

Joining the outstanding original research and invited materials already appearing in the Clinical Journal of the American Society of Nephrology ( CJASN ), a new feature, Clinical Conferences, appears for the first time in this issue. This feature is designed to expand our emphasis on practical information for clinicians and is organized and edited by Ajay Singh of Brigham and Women's Hospital and by Charles Alpers of the University of Washington. We will periodically publish Clinical Conferences from academic health centers where expert clinicians discuss a particularly challenging case. This issue's inaugural Conference on light chain deposition disease is discussed by David Salant, Vaishali Sanchorawala, and Vivette D'Agati. This new Clinical Conference feature will supplement CJASN's published versions of the ClinicoPathologic Conference (CPC) and Nephrology Quiz that are presented each year at the annual meeting of the American Society of Nephrology. You will see these articles in subsequent issues. By providing these features, CJASN hopes to make analyses as well as diagnostic and therapeutic approaches by acknowledged experts accessible to clinicians. We sincerely hope that our readers enjoy this new feature as well as the annual CPC and Nephrology Quiz. CJASN 's entire editorial team would also like to thank the readership for their support of the Journal . We look forward to receiving feedback on the CJASN Clinical Conference.William M. Bennett, MD Harold I. Feldman, MD Mohamed H. Sayegh, MD The patient is a 70-yr-old retired schoolteacher who had been in good health until he was found to have asymptomatic proteinuria (approximately 1 g/24 h) on routine physical examination. He was mildly hypertensive, and serum creatinine was 1.2 mg/dl with a measured creatinine clearance of 78 ml/min.The patient's past medical history was significant for mild hypertension, hyperlipidemia, diet-controlled glucose intolerance (HbA1c 5.2), an intentional weight loss of 15 …