Hypothesis | Zendy

Lawrence Copelovitch | Zendy; Martin A. Nash | Zendy; Bernard S. Kaplan | Zendy

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Hypothesis

Author(s) -

Lawrence Copelovitch,

Martin A. Nash,

Bernard S. Kaplan

Publication year - 2007

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.00900207

Subject(s) - medicine , asymptomatic , proteinuria , nephrocalcinosis , hypercalciuria , focal segmental glomerulosclerosis , renal biopsy , disease , biopsy , pediatrics , urology , gastroenterology , urinary system , kidney

Dent disease is a hereditary form of progressive renal failure characterized by hypercalciuria and proximal tubular dysfunction. The clinical presentation is often insidious with the majority of patients remaining asymptomatic throughout childhood. Despite the seemingly mild, early course, more than 20% of 32 asymptomatic patients in one study had biopsy evidence of focal glomerulosclerosis. Furthermore, end-stage renal disease often occurs in men in early to middle adulthood.

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