Incidence and Outcomes of BK Virus Allograft Nephropathy among ABO- and HLA-Incompatible Kidney Transplant Recipients | Zendy

Adnan Sharif | Zendy; Nada Alachkar | Zendy; Serena M. Bagnasco | Zendy; Duvuru Geetha | Zendy; Gaurav Gupta | Zendy; Karl L. Womer | Zendy; Lois J. Arend | Zendy; Lorraine C. Racusen | Zendy; Robert A. Montgomery | Zendy; Edward S. Kraus | Zendy

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Incidence and Outcomes of BK Virus Allograft Nephropathy among ABO- and HLA-Incompatible Kidney Transplant Recipients

Author(s) -

Adnan Sharif,

Nada Alachkar,

Serena M. Bagnasco,

Duvuru Geetha,

Gaurav Gupta,

Karl L. Womer,

Lois J. Arend,

Lorraine C. Racusen,

Robert A. Montgomery,

Edward S. Kraus

Publication year - 2012

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.00770112

Subject(s) - medicine , abo blood group system , kidney transplantation , incidence (geometry) , transplantation , nephropathy , renal function , urology , gastroenterology , endocrinology , diabetes mellitus , physics , optics

ABO-incompatible kidney transplant recipients may have a higher incidence of BK virus allograft nephropathy (BKVAN) compared with ABO-compatible recipients. It is unclear whether HLA-incompatible recipients share this risk or whether this phenomenon is unique to ABO-incompatible recipients. DESIGN, SETTING, PARTICIPATION, MEASUREMENTS: This study analyzed adult incompatible kidney transplant recipients from 1998 to 2010 (62 ABO-incompatible and 221 HLA-incompatible) and identified patients in whom BKVAN was diagnosed by biopsy (per protocol or for cause). This was a retrospective analysis of a prospectively maintained database that compared BKVAN incidence and outcomes between ABO- and HLA-incompatible recipients, respectively. BKVAN link to rejection and graft accommodation phenotype were also explored. The Johns Hopkins Institutional Review Board approved this study.

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