Thrombotic Microangiopathy and the Kidney | Zendy

Vicky Brocklebank | Zendy; Katrina M. Wood | Zendy; David Kavanagh | Zendy

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Thrombotic Microangiopathy and the Kidney

Author(s) -

Vicky Brocklebank,

Katrina M. Wood,

David Kavanagh

Publication year - 2017

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.00620117

Subject(s) - thrombotic microangiopathy , medicine , microangiopathic hemolytic anemia , microangiopathy , intensive care medicine , pathogenesis , epidemiology , acute kidney injury , schistocyte , pathology , gastroenterology , thrombotic thrombocytopenic purpura , platelet , diabetes mellitus , disease , endocrinology

Thrombotic microangiopathy can manifest in a diverse range of diseases and is characterized by thrombocytopenia, microangiopathic hemolytic anemia, and organ injury, including AKI. It can be associated with significant morbidity and mortality, but a systematic approach to investigation and prompt initiation of supportive management and, in some cases, effective specific treatment can result in good outcomes. This review considers the classification, pathology, epidemiology, characteristics, and pathogenesis of the thrombotic microangiopathies, and outlines a pragmatic approach to diagnosis and management.

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