Mechanisms and Role of HLA and non-HLA Alloantibodies | Zendy

Kathryn Tinckam | Zendy; Anil Chandraker | Zendy

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Mechanisms and Role of HLA and non-HLA Alloantibodies

Author(s) -

Kathryn Tinckam,

Anil Chandraker

Publication year - 2006

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.00270106

Subject(s) - medicine , human leukocyte antigen , immunology , pathogenesis , antibody , complement system , isoantibodies , antigen , histocompatibility testing

The role of alloantibodies against HLA and non-HLA targets is becoming increasingly recognized as critical in the pathogenesis of acute and chronic renal allograft outcomes. This review discusses the antigenic targets, the mechanisms of T and B cell activation that result in the production of antibody, the complement cascade, methods of antibody detection, and the evidence that alloantibody-mediated mechanisms are active in acute and chronic rejection.

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