Open AccessMultiple-Dose Pharmacokinetics and Pharmacodynamics of N-Acetylcysteine in Patients with End-Stage Renal Disease
Author(s) -
Thomas D. Nolin,
Rosemary Ouseph,
Jonathan Himmelfarb,
Maggie McMenamin,
Richard Ward
Publication year - 2010
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.00210110
Subject(s) - medicine , end stage renal disease , pharmacokinetics , pharmacodynamics , acetylcysteine , disease , pharmacology , intensive care medicine , biochemistry , chemistry , antioxidant
ESRD is associated with systemic oxidative stress, an important nontraditional risk factor for the development of cardiovascular disease. Since interventions aimed at reducing oxidative stress may be beneficial, we examined the pharmacokinetics and pharmacodynamics of the widely used antioxidant N-acetylcysteine (NAC) after oral administration in patients with ESRD.
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