Metabolism, Protein Binding, and Renal Clearance of Microbiota–Derived p-Cresol in Patients with CKD | Zendy

Ruben Poesen | Zendy; Pieter Evenepoel | Zendy; Henriëtte de Loor | Zendy; Dirk Kuypers | Zendy; Patrick Augustijns | Zendy; Björn Meijers | Zendy

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Metabolism, Protein Binding, and Renal Clearance of Microbiota–Derived p-Cresol in Patients with CKD

Author(s) -

Ruben Poesen,

Pieter Evenepoel,

Henriëtte de Loor,

Dirk Kuypers,

Patrick Augustijns,

Björn Meijers

Publication year - 2016

Publication title -

clinical journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.755

H-Index - 151

eISSN - 1555-905X

pISSN - 1555-9041

DOI - 10.2215/cjn.00160116

Subject(s) - cresyl violet , glucuronide , medicine , sulfate , endocrinology , urine , metabolite , confidence interval , chemistry , pathology , staining , organic chemistry

Colonic microbial metabolism substantially contributes to uremic retention solutes in CKD. p-Cresyl sulfate is the main representative of this group of solutes, relating to adverse outcomes. Other than sulfate conjugation, p-cresol is subjected to endogenous glucuronide conjugation. Whether the balance between sulfate and glucuronide conjugation is relevant in CKD is unexplored.

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