Gender and the Renal Nitric Oxide Synthase System in Healthy Humans
Author(s) -
Sofia B. Ahmed,
Naomi D.L. Fisher,
Norman K. Hollenberg
Publication year - 2007
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.00110107
Subject(s) - nitric oxide , medicine , renal blood flow , nitric oxide synthase , kidney , endocrinology , blood pressure , hemodynamics , disease , physiology , cardiology
It is widely known that men with kidney disease progress to ESRD at a much greater rate than do women. The mechanism for these gender differences is not clear, but reduced availability of nitric oxide is thought to contribute to the age-related decline in renal plasma flow observed in both healthy men and women. Animal models suggest that the renal vasculature of men may be significantly more dependent on nitric oxide than that of women.
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