Open AccessSYNTHESIS OF UK-3A ANALOGUE AND ASSAY ON P 388 MURINE LEUKEMIA CELLS
Author(s) -
Yulia Anita,
M. Hanafi,
Amj Putra,
S. Arifin,
Yoshinosuke Usuki,
H Iio
Publication year - 2010
Language(s) - English
DOI - 10.22146/ijc.426
UK-3A is secondary metabolite of Streptomyces sp.517-02 which has IC50 38 μg/mL against P388 Murine Leukemia cells. An analogue of UK-3A was synthesized from L-methyl serine as the starting material by amidation and esterification. An analogue UK-3A was analyzed and identified by TLC, FT-IR, LC-MS and NMR spectrometer. It was found to have IC50 15.4μg/mL against the same Leukemia cells. The overall yield was 87.10%.
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