A New Polyketide from the Endophytic Fungus Penicillium chermesinum | Zendy

Cici Darsih | Zendy; Vilailak Prachyawarakorn | Zendy; Chulabhorn Mahidol | Zendy; Somsak Ruchirawat | Zendy; Prasat Kittakoop | Zendy

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A New Polyketide from the Endophytic Fungus <i>Penicillium chermesinum</i>

Author(s) -

Cici Darsih,

Vilailak Prachyawarakorn,

Chulabhorn Mahidol,

Somsak Ruchirawat,

Prasat Kittakoop

Publication year - 2017

Publication title -

indonesian journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.273

H-Index - 14

eISSN - 2460-1578

pISSN - 1411-9420

DOI - 10.22146/ijc.22273

Subject(s) - chemistry , polyketide , penicillium , fungus , cytotoxicity , plant use of endophytic fungi in defense , stereochemistry , cancer cell lines , two dimensional nuclear magnetic resonance spectroscopy , botany , cancer cell , food science , biochemistry , gene , cancer , biosynthesis , in vitro , biology , genetics

A new polyketide derivative, 2-chloro-3,4,7-trihydroxy-9-methoxy-1-methyl-6H-benzo[c]chromen-6-one ( 1 ), was isolated from the endophytic fungus Penicillium chermesinum . The structure was established on the basis of UV, IR, HR-ESI MS, and 1D and 2D NMR experiments. The cytotoxicity against four cancer cell lines (HuCCA-1, HepG2, A-549, and MOLT-3) of compound 1 are 14.94-115.71 µM.

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