THE EFFECT OF HYDROGEL DRESSING COPOLYMER POLI(VINYLPIRROLIDONE) (PVP) - k- CARRAGEENAN PREPARED BY RADIATION AND HEALING TIMES ON THE RADIUS REDUCTIONS BURN INJURIED OF WISTAR WHITE RAT | Zendy

Erizal Erizal | Zendy

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THE EFFECT OF HYDROGEL DRESSING COPOLYMER POLI(VINYLPIRROLIDONE) (PVP) - k- CARRAGEENAN PREPARED BY RADIATION AND HEALING TIMES ON THE RADIUS REDUCTIONS BURN INJURIED OF WISTAR WHITE RAT

Author(s) -

Erizal Erizal

Publication year - 2010

Publication title -

indonesian journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.273

H-Index - 14

eISSN - 2460-1578

pISSN - 1411-9420

DOI - 10.22146/ijc.21633

Subject(s) - self healing hydrogels , carrageenan , chemistry , ultimate tensile strength , aqueous solution , copolymer , nuclear chemistry , n vinylpyrrolidone , irradiation , swelling , polymer chemistry , sterilization (economics) , chemical engineering , composite material , polymer , materials science , organic chemistry , food science , foreign exchange , monetary economics , foreign exchange market , economics , engineering , physics , nuclear physics

The pre-clinical study of poly (vinyl pirrolidone) (PVP)-κcarrageenan hydrogel has been carried out. The aim of this study is to investigate the effect of hydrogel for healing burn injuried in the rats. The hydrogels were prepared by γ-irradiation of aqueous solutions of 15 wt.-% PVP and 2 wt.-% κcarrageenan at a sterilization dose of 25 kGy. The physico-chemical properties of hydrogels were investigated. The results showed that the hydrogels suitable as candidate for wound dressing with gel fraction of 90 ± 5 (%), the water absorption was 4500 ± 55 (w/w), the water content was 83 ± 2 (%), tensile strength was 1,5 ± 0,1 kg/cm and adhesiveness was 0. The effect of the hydrogel as wound dressing was evaluated by attaching to a burn of the back skin of rats as a function of time observation. Advantages of the hydrogel were slightly faster rate of reducing radius diameter of injured burn skin, easy removal without damage to renewed skin.

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