MOLECULAR DOCKING OF D6-ANHYDROERYTHROMYCIN TO rRNA 23S Deinococcus radiodurans AND THE PREDICTION OF ITS ANTIBIOTIC POTENCY | Zendy

Winarto Haryadi | Zendy; Umar Anggara Jenie | Zendy; Retno S. Sudibyo | Zendy; Harno Dwi Pranowo | Zendy; Fajar Rakhman Wibowo | Zendy

Open Access

MOLECULAR DOCKING OF D6-ANHYDROERYTHROMYCIN TO rRNA 23S Deinococcus radiodurans AND THE PREDICTION OF ITS ANTIBIOTIC POTENCY

Author(s) -

Winarto Haryadi,

Umar Anggara Jenie,

Retno S. Sudibyo,

Harno Dwi Pranowo,

Fajar Rakhman Wibowo

Publication year - 2010

Publication title -

indonesian journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.273

H-Index - 14

eISSN - 2460-1578

pISSN - 1411-9420

DOI - 10.22146/ijc.21546

Subject(s) - deinococcus radiodurans , chemistry , docking (animal) , macromolecule , 23s ribosomal rna , ribosomal rna , stereochemistry , biochemistry , dna , ribosome , rna , medicine , nursing , gene

-anhidroeritromisin-A is a new derivative of erythromycin which is synthesized through biosynthetic engineering technique. The molecular docking in rRNA 23S Deinoccocus radiodurans are accomplished to determine the model and strength of binding to the target macromolecule. The molecular docking of erythromycin-A and 6-deoksieritromisin-A to the same macromolecule is used as a control. The docking result of the anhidroeritromisin-A shows that it occupies the same cavity as of the experimental erythromycin-A in the same macromolecule. The binding position of -anhidroeritromisin-A is not exactly same as erythromycin-A and 6deoksieritromisin-A due to the presence of unsaturated double bond. However the hydroxyl group(OH) at C-6 does not have an apparent effect on the binding model to rRNA23S D. radiodurans.

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