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-anhidroeritromisin-A is a new derivative of erythromycin which is synthesized through biosynthetic engineering technique. The molecular docking in rRNA 23S Deinoccocus radiodurans are accomplished to determine the model and strength of binding to the target macromolecule. The molecular docking of erythromycin-A and 6-deoksieritromisin-A to the same macromolecule is used as a control. The docking result of the anhidroeritromisin-A shows that it occupies the same cavity as of the experimental erythromycin-A in the same macromolecule. The binding position of -anhidroeritromisin-A is not exactly same as erythromycin-A and 6deoksieritromisin-A due to the presence of  unsaturated double bond. However the hydroxyl group(OH) at C-6 does not have an apparent effect on the binding model to rRNA23S D. radiodurans.

indonesian journal of chemistry

MOLECULAR DOCKING OF &lt;p&gt;&lt;em&gt;D&lt;/em&gt;&lt;em&gt;&lt;sup&gt;6&lt;/sup&gt;-ANHYDROERYTHROMYCIN TO rRNA 23S Deinococcus radiodurans AND THE PREDICTION OF ITS ANTIBIOTIC POTENCY