Biotransformation and Cytotoxic Activity of Guaiacol Dimer | Zendy

Galuh Widiyarti | Zendy; Jamilah Abbas | Zendy; Yulia Anita | Zendy

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Biotransformation and Cytotoxic Activity of Guaiacol Dimer

Author(s) -

Galuh Widiyarti,

Jamilah Abbas,

Yulia Anita

Publication year - 2014

Publication title -

indonesian journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.273

H-Index - 14

eISSN - 2460-1578

pISSN - 1411-9420

DOI - 10.22146/ijc.21256

Subject(s) - guaiacol , chemistry , biotransformation , enzyme , in vitro , cytotoxic t cell , dimer , mtt assay , biochemistry , stereochemistry , organic chemistry

Guaiacol, a phenolic compound is known as an anticancer. Dimerization of guaiacol has been done by biotransformation using peroxidase enzyme as biocatalyst. This enzyme was isolated from Indonesian plant, kailan ( Brassica oleraceae var. alboglabra ). Analysis of dimerization product was carried out by TLC, IR, LC-MS, and NMR. Whilst a nalysis of in-vitro cytotoxic activity was carried out by MTT method against breast cancer T47D and MCF7 cells. The result showed that the dimerization reaction gave O-para dehydroguaiacol. T he in-vitro cytotoxic activity analysis showed that O-para dehydroguaiacol compound has potency as anti-breast cancer.

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