Open AccessDetection of pulmonary emboli by using MR angiography with MPEG-PL-GdDTPA: an experimental study in rabbits.
Author(s) -
Howard A. Frank,
R. Weissleder,
Alexei A. Bogdanov,
T J Brady
Publication year - 1994
Publication title -
american journal of roentgenology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.294
H-Index - 196
eISSN - 1546-3141
pISSN - 0361-803X
DOI - 10.2214/ajr.162.5.8165978
Subject(s) - medicine , angiography , radiology , contrast (vision) , pulmonary embolism , pulmonary vasculature , nuclear medicine , pulmonary hypertension , artificial intelligence , computer science
A macromolecular MR contrast agent (MPEG-PL-GdDTPA), which consists of Gd-DTPA covalently attached to a polyamino acid (PL) derivatized by monomethoxy ether of polyethylene glycol (MPEG), has recently been developed. This contrast agent exhibits long intravascular retention, which makes it suitable for MR angiography. The current study was performed to test whether this agent would improve visualization of the pulmonary vasculature during MR angiography and whether it aids in the detection of pulmonary emboli in an animal model.