Open AccessComplications of intraarterial urokinase-lys-plasminogen infusion therapy in arterial ischemia of lower limbs
Author(s) -
Fiessinger Jn,
Vitoux Jf,
Pernès Jm,
M Roncato,
Martine Aiach,
J G Gaux
Publication year - 1986
Publication title -
american journal of roentgenology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.294
H-Index - 196
eISSN - 1546-3141
pISSN - 0361-803X
DOI - 10.2214/ajr.146.1.157
Subject(s) - medicine , urokinase , thrombolysis , thrombosis , surgery , fibrinolysis , heparin , ischemia , hematoma , catheter , groin , bolus (digestion) , anesthesia , cardiology , myocardial infarction
Thirty-five patients with peripheral arterial occlusions were treated by intraarterial infusion of low-dose urokinase associated with bolus of lys-plasminogen. Thrombolysis was achieved in 26 cases (74%), but only 10 patients (28.5%) experienced sustained improvement. Complications of thrombolysis occurred in 11 patients: Five patients developed groin hematoma, five had distal emboli, and one experienced macroscopic hematuria. Catheter-related thrombosis was observed in 14 patients (40%) despite intravenous heparin. Nine patients suffered from recurrent thrombosis and three from proximal emboli. A patient died from catheter-related infection. Limited fibrinolysis could increase pericatheter thrombosis, and further work will be necessary to assess the local risk of intraarterial thrombolysis.