Open AccessTransformation delay of lymphocytes in patients undergoing radiation therapy
Author(s) -
T. Merz,
Rudranil Hazra,
Merrill Ross,
Linda J. Ciborowski
Publication year - 1976
Publication title -
american journal of roentgenology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.294
H-Index - 196
eISSN - 1546-3141
pISSN - 0361-803X
DOI - 10.2214/ajr.127.2.337
Subject(s) - medicine , immune system , radiation therapy , thymidine , lymphocyte , lung cancer , nuclear medicine , oncology , cancer research , immunology , dna , genetics , biology
Two types of assay systems to measure the effect of radiation on immune competence are described. The first, transformation, is measured by blast formation or uptake and incorporation of tritiated thymidine by lumphocytes. This measure is affected by a number of known cell responses to radiation such as division delay and delay in DNA synthesis. The second, called Bactec, is designed to measure lymphocyte metabolic acitivty. Data gathered on 37 patients with lung cancer show that the Bactec system provides a better index of the patient's immune status before and after radiation therapy.