PET With 62Cu-ATSM and 62Cu-PTSM Is a Useful Imaging Tool for Hypoxia and Perfusion in Pulmonary Lesions | Zendy

Tian Zhang | Zendy; Shiva K. Das | Zendy; Diane Fels | Zendy; Katherine Hansen | Zendy; Terence Z. Wong | Zendy; Mark W. Dewhirst | Zendy; Gordana Vlahovic | Zendy

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PET With ⁶²Cu-ATSM and ⁶²Cu-PTSM Is a Useful Imaging Tool for Hypoxia and Perfusion in Pulmonary Lesions

Author(s) -

Tian Zhang,

Shiva K. Das,

Diane Fels,

Katherine Hansen,

Terence Z. Wong,

Mark W. Dewhirst,

Gordana Vlahovic

Publication year - 2013

Publication title -

american journal of roentgenology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.294

H-Index - 196

eISSN - 1546-3141

pISSN - 0361-803X

DOI - 10.2214/ajr.12.9698

Subject(s) - hypoxia (environmental) , medicine , perfusion , pet imaging , nuclear medicine , lung , perfusion scanning , tumor hypoxia , radiology , cancer research , positron emission tomography , radiation therapy , chemistry , oxygen , organic chemistry

Hypoxia is a characteristic of many tumors and portends a worse prognosis in lung, cervical, prostate, and rectal cancers. Unlike the others, lung cancers present a unique challenge in measuring hypoxia, with invasive biopsies and higher rates of complications. Noninvasive imaging studies detecting hypoxia using isotopes of copper-diacetyl-bis(N4-methylthiosemicarbazone) ((62)Cu-ATSM) have predicted prognosis and treatment outcomes in some small feasibility trials. These images, however, may not identify all areas of hypoxia. Hence, we hypothesize that the addition of another PET imaging agent, copper-pyruvaldehyde-bis(N4-methylthiosemicarbazone) ((62)Cu-PTSM), which can detect areas of perfusion, can augment the information obtained in (62)Cu-ATSM PET scans.

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