Synthesis of New β-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities | Zendy

Aliasghar Jarrahpoura | Zendy; Roghayeh Heiran | Zendy; Véronique Sinouc | Zendy; Christine Latourc | Zendy; Lamia Djouhri Bouktabd | Zendy; Jean Michel Brunel | Zendy; Javed Sheikhe | Zendy; Taibi Ben Haddaf | Zendy

Open Access

Synthesis of New β-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities

Author(s) -

Aliasghar Jarrahpoura,

Roghayeh Heiran,

Véronique Sinouc,

Christine Latourc,

Lamia Djouhri Bouktabd,

Jean Michel Brunel,

Javed Sheikhe,

Taibi Ben Haddaf

Publication year - 2019

Publication title -

hal (le centre pour la communication scientifique directe)

Language(s) - English

DOI - 10.22037/ijpr.2019.2348

Subject(s) - morpholine , antimicrobial , ring (chemistry) , chemistry , combinatorial chemistry , biological activity , stereochemistry , bearing (navigation) , organic chemistry , biochemistry , computer science , in vitro , artificial intelligence

Some new β-lactams bearing biologically important morpholine ring have been synthesized by acylation of amino β-lactams in the presence of morpholine-4-carbonyl chloride. These novel β-lactams were prepared under mild reaction conditions without any solvent in short reaction times. Their biological activities have been examined against microbial agents such as Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) and fungi such as Candida albicans (C. albicans) and Candida glabrata (C. glabrata). They have been also tested against Plasmodium falciparum K14 resistant strain and showed moderate to good IC50 values.

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