Functionalization of MWNT-COOH by one-step reaction with (3-oxoindolin-2-ylidene) urea and in vitro antitumor study on gastric cancer

Aim In this study, we was tried to prepare a nano compound with a new way in functionalization as anti gastric cancer candidate. Background Functionalization of nanotubes is a useful route for modification of their biologic properties. (3-oxoindolin-2-ylidene) urea is a chemical compound that made of isatin and urea that can be useful in cancer study. Patients and methods MWNT-COOH was functionalized by this compound with one-step reaction that is a new class in modification. Product has been investigated by FT-IR, Raman and SEM. Anti cancer investigation with human gastric cells and MTT assay test for measurement of viable cell numbers were also performed. Results The two bands at around 2800–2900 cm−1 which are seen in functionalized product are attributed to the CH stretching of MWNT–COOH defects. Conclusion Cellular results demonstrated that the functionalized nano-tube is a more toxic agent compared to other samples for cancer cells and can be used as a candidate material for chemotherapy.