Disruption of FGF2-Heparin-FGFR1 Complex Formation by Antiangiogenic Small Molecule Found In Silico

Angiogenesis is a physiological process consist in the sprouting of nascent vasculature from existing blood vessels. It is now widely recognized that angiogenic activity is also crucial in the progress of tumors and metastasis [1, 2]. Therefore, angiogenesis inhibition has become an appealing therapeutic strategy for cancer [3]. The tumors recruit blood vessels from the surrounding tissue to induce the growth of blood vessels to supply them with oxygen and nutrients. Basic fibroblast growth factor (FGF2), is one of the most potent proangiogenic proteins that has been shown to influence proliferation, migration, and differentiation of cells [4-7]. As it plays in important conditions, structural-functional relationship studies on FGF2 are of large interest. This growth factor needs to Abstract