Drosophila MelanogasterShow a Threshold Effect in Response to Radiation | Zendy

Michael Antosh | Zendy; David J. Fox | Zendy; Thomas Hasselbacher | Zendy; R. E. Lanou | Zendy; Nicola Neretti | Zendy; Leon N. Cooper | Zendy

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Drosophila MelanogasterShow a Threshold Effect in Response to Radiation

Author(s) -

Michael Antosh,

David J. Fox,

Thomas Hasselbacher,

R. E. Lanou,

Nicola Neretti,

Leon N. Cooper

Publication year - 2014

Publication title -

dose-response

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.502

H-Index - 36

ISSN - 1559-3258

DOI - 10.2203/dose-response.13-047.antosh

Subject(s) - drosophila melanogaster , radiation , radiation effect , biology , melanogaster , drosophila (subgenus) , ionizing radiation , biological effect , radiation dose , irradiation , gene , genetics , medicine , physics , optics , nuclear medicine , endocrinology , nuclear physics

We investigate the biological effects of radiation using adult Drosophila melanogaster as a model organism, focusing on gene expression and lifespan analysis to determine the effect of different radiation doses. Our results support a threshold effect in response to radiation: no effect on lifespan and no permanent effect on gene expression is seen at incident radiation levels below 100 J/kg. We also find that it is more appropriate to compare radiation effects in flies using the absorbed energy rather than incident radiation levels.

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