Open AccessDrosophila MelanogasterShow a Threshold Effect in Response to Radiation
Author(s) -
Michael Antosh,
David J. Fox,
Thomas Hasselbacher,
R.E. Lanou,
Nicola Neretti,
Leon N. Cooper
Publication year - 2014
Publication title -
dose-response
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.502
H-Index - 36
ISSN - 1559-3258
DOI - 10.2203/dose-response.13-047.antosh
Subject(s) - drosophila melanogaster , radiation , radiation effect , biology , melanogaster , drosophila (subgenus) , ionizing radiation , biological effect , radiation dose , irradiation , gene , genetics , medicine , physics , optics , nuclear medicine , endocrinology , nuclear physics
We investigate the biological effects of radiation using adult Drosophila melanogaster as a model organism, focusing on gene expression and lifespan analysis to determine the effect of different radiation doses. Our results support a threshold effect in response to radiation: no effect on lifespan and no permanent effect on gene expression is seen at incident radiation levels below 100 J/kg. We also find that it is more appropriate to compare radiation effects in flies using the absorbed energy rather than incident radiation levels.