The Temporal Hormesis of Drug Therapies | Zendy

Noor B. Dudekula | Zendy; Vikas Arora | Zendy; Zsuzsanna CallaertsVegh | Zendy; Richard A. Bond | Zendy

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The Temporal Hormesis of Drug Therapies

Author(s) -

Noor B. Dudekula,

Vikas Arora,

Zsuzsanna CallaertsVegh,

Richard A. Bond

Publication year - 2005

Publication title -

dose-response

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.502

H-Index - 36

ISSN - 1559-3258

DOI - 10.2203/dose-response.003.03.009

Subject(s) - hormesis , medicine , drug , intensive care medicine , agonist , phenomenon , pharmacology , receptor , oxidative stress , physics , quantum mechanics

Recent publications in the field of asthma therapeutics and studies performed over the last decade in the treatment of chronic heart failure suggest a phenomenon called 'temporal hormesis'. This phenomenon can be defined as the beneficial action of drug after chronic administration as opposed to its detrimental acute effects. Temporal hormesis may be related to the classification of the drug molecule as an agonist, antagonist or an inverse agonist. This phenomenon may be a more general principal applicable in the treatment of other diseases apart from asthma and chronic heart failure.

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