A Curious Case of Multiple Myeloma Hidden in a Cloud of Severe Cryoglobulinemia | Zendy

Naomi Fei | Zendy; Abraham S. Kanate | Zendy

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A Curious Case of Multiple Myeloma Hidden in a Cloud of Severe Cryoglobulinemia

Author(s) -

Naomi Fei,

Abraham S. Kanate

Publication year - 2017

Publication title -

west virginia medical journal

Language(s) - English

Resource type - Journals

ISSN - 0043-3284

DOI - 10.21885/wvmj.2017.14

Subject(s) - cryoglobulinemia , cryoglobulins , hyperviscosity syndrome , hyperviscosity , plasma cell dyscrasia , medicine , dyscrasia , pathology , monoclonal gammopathy , cryoglobulin , multiple myeloma , immunology , gastroenterology , monoclonal , dermatology , antibody , plasma cell , monoclonal antibody , blood viscosity , hepatitis c virus , virus , immunoglobulin light chain

Cryoglobulins are proteins that form ‘cloudy’ precipitates at temperatures <37°C. In type I cryoglobulinemia, the causative protein is a monoclonal immunoglobulin due to an underlying plasma cell dyscrasia. Cryoglobulinemia can present with hyperviscosity syndrome, characterized by headache, fatigue, and blurred vision. In episodes of severe cryoglobulinemia, premature precipitation of proteins can lead to falsely negative diagnostic tests and complications with treatment. The following case exemplifies the complications of diagnosis and treatment of cryoglobulinemia with hyperviscosity syndrome.

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