Molecular Characterization and Phylogenetic Study of Newcastle Disease Viruses Isolated in Iran, 2014–2015 | Zendy

Mohammad Kiani | Zendy; M H Bozorgmehrifard | Zendy; Hossein Hosseini | Zendy; Saied Charkhkar | Zendy; A Ghalyanchi | Zendy

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Molecular Characterization and Phylogenetic Study of Newcastle Disease Viruses Isolated in Iran, 2014–2015

Author(s) -

Mohammad Kiani,

M H Bozorgmehrifard,

Hossein Hosseini,

Saied Charkhkar,

A Ghalyanchi

Publication year - 2016

Publication title -

iranian journal of virology

Language(s) - English

Resource type - Journals

eISSN - 2588-5030

pISSN - 1735-5680

DOI - 10.21859/isv.10.2.3.53

Subject(s) - phylogenetic tree , newcastle disease , virology , biology , phylogenetics , disease , phylogenetic relationship , virus , genetics , gene , medicine , pathology

Newcastle disease (ND) is a highly contagious disease that affects many species of birds and causes significant economic losses to the poultry industry worldwide and the pathogenicity of Newcastle disease virus (NDV) strains varies with different virulence. Samples were collected from chicken commercial farms in Iran during 2014–2015. ND virus was characterized (NDV) by partial sequences of fusion genome and compared with other NDV sequences. All viruses showed the amino acid sequence 112 RRQKRF117 at the C-terminus of the F2 protein and phenylalanine at the N-terminus of the F1 protein, residue 117. These amino acid sequences were identical to a known virulent motif. Based on the phylogenetic analysis the Iranian NDV isolates are closely related to the genotype VIId of class II NDV strains. The result showed that the genotype VIId was dominant and circulating among chicken farms and caused clinical disease.

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