Peganum harmala seed extract can prevent HSV-1 replication in vitro | Zendy

Seyed Jalal Kiani | Zendy; M Shamsi Shahrabadi | Zendy; Angila Ataei | Zendy; Nancy Sajjadi | Zendy

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Peganum harmala seed extract can prevent HSV-1 replication in vitro

Author(s) -

Seyed Jalal Kiani,

M Shamsi Shahrabadi,

Angila Ataei,

Nancy Sajjadi

Publication year - 2007

Publication title -

iranian journal of virology

Language(s) - English

Resource type - Journals

eISSN - 2588-5030

pISSN - 1735-5680

DOI - 10.21859/isv.1.4.11

Subject(s) - peganum harmala , vero cell , herpes simplex virus , biology , virology , in vitro , traditional medicine , microbiology and biotechnology , virus , medicine , botany , biochemistry

Peganum harmala L. (Zygophylaceae) has been used in a variety of practical applications in medical science. Our objective in the current study was to determine the effects of the seed extract on Herpes simplex virus type 1 (HSV-1) replication in Vero cells. Different concentrations (100, 500, 571, 667, 800 and 1000 μg/ml) of the extract were examined. Experiments were carried out using Vero cells. P.harmala seed extract was found to be non-toxic to Vero cells up to a concentration of 667 μg/ml. The antiviral activity of nontoxic concentration against HSV-1 was tested. The replication of HSV-1 was inhibited, indicating that the P.harmala L. extract contains an anti-HSV-1 substance.

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