ADAMTS-1 Expression in Cumulus Cells: A Biomarker for Oocyte Maturity | Zendy

Sepide Gohari taban | Zendy; Iraj Amiri | Zendy; Massoud Saidijam | Zendy; Sara Soleimani Asl | Zendy; Mahnaz Yavangi | Zendy; Elham Khanlarzadeh | Zendy; Tayebe Artimani | Zendy

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ADAMTS-1 Expression in Cumulus Cells: A Biomarker for Oocyte Maturity

Author(s) -

Sepide Gohari taban,

Iraj Amiri,

Massoud Saidijam,

Sara Soleimani Asl,

Mahnaz Yavangi,

Elham Khanlarzadeh,

Tayebe Artimani

Publication year - 2018

Publication title -

avicenna journal of clinical medicine

Language(s) - English

Resource type - Journals

eISSN - 2588-7238

pISSN - 2588-722X

DOI - 10.21859/ajcm.24.4.263

Subject(s) - oocyte , adamts , andrology , cumulus oophorus , follicular phase , in vitro fertilisation , biology , microbiology and biotechnology , metalloproteinase , chemistry , thrombospondin , embryo , medicine , endocrinology , matrix metalloproteinase , genetics

Background and Objective: Cumulus cells regulate oocyte maturation through bilateral communication during follicular growth. Expression of disintegrin-like and metalloproteinase with thrombospondin type I motifs-1 (ADAMTS-1) is essential for structural remodeling during the follicle growth, to maintain normal granulosa cell layers in the follicles. Since limited studies have been performed on this issue, we aimed to evaluate the expression of ADAMTS-1 in human cumulus cells and the possible correlation between ADAMTS-1 expression and oocyte maturity. Materials and Methods: Fifty infertile women aged 18-40 years undergoing in vitro fertilization (IVF) were recruited. The participants had tubal obstruction and/or their partners were diagnosed with male factor infertility. Cumulus cells were obtained immediately after the isolation of cumulusoocyte complexes. Adamts-1 and β-actin mRNA expression levels were measured using quantitative real-time polymerase chain reaction (qRT-

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