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The objective of the research was to study the features of impaired fibrinolytic and proteolytic activity of blood plasma in patients with osteoarthritis (OA), depending on the age levels of comorbidity.Material and methods. The age features of comorbid processes prevalence in 120 patients with OA were clinically studied, fibrinolytic and proteolytic activity of blood, levels of fibrinogen and C-reactive protein were also studied using biochemical methods.Results. Comorbidity in patients with OA at the age under 50 was established low. The level of comorbidity increases to at the age of 51-60, after 60 years the phenomenon of comorbidity is more significant by frequency and severity. The diseases of the cardiovascular system dominated, including metabolic syndrome, diseases of the digestive tract and kidneys were less frequent. Cardiovascular risk (CVR) levels were high after the age of 50, gastrointestinal risk was less frequent. Fibrinolysis minor disorders were observed in patients with low comorbidity, namely fibrinolytic and proteolytic activity of blood as a part of high CVR progressively deteriorated and the level of fibrinogen and C-reactive protein increased in the patients at the age after 50 (especially 60) on the background of high comorbidity levels. Conclusions. The level of comorbidity and CVR increased in patients with OA with age, increase in disease severity and duration. These phenomena were accompanied by progressive disorders in fibrinolytic and proteolytic activity of the blood, increased levels of fibrinogen and C-reactive protein as one of the components of CVR.

Main Features of Impaired Fibronolytic and Protolytic Activity of Blood Plasma in Patients with Osteoarthritis Depending on Comorbidity