ASSOCIATION BETWEEN CARBAMAZEPINE INDUCED SEVERE CUTANEOUS ADVERSE DRUG REACTION AND HLA POLIMORPHISMS | Zendy

Safrina Dewi Ratnaningrum | Zendy

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ASSOCIATION BETWEEN CARBAMAZEPINE INDUCED SEVERE CUTANEOUS ADVERSE DRUG REACTION AND HLA POLIMORPHISMS

Author(s) -

Safrina Dewi Ratnaningrum

Publication year - 2016

Publication title -

mnj (malang neurology journal)

Language(s) - English

Resource type - Journals

eISSN - 2442-5001

pISSN - 2407-6724

DOI - 10.21776/ub.mnj.2016.002.01.7

Subject(s) - carbamazepine , human leukocyte antigen , adverse drug reaction , drug , hla b , medicine , drug reaction , adverse effect , hla b antigens , immunology , pharmacology , antigen , psychiatry , epilepsy

Carbamazepine as an antiepileptic drug that is used widely and was known can cause severe cutaneous adverse drug reactions like SJS-TEN. These adverse drug reactions is known to be associated with some specific HLA polymorphism in European populations (HLA-A*31: 01), China (HLA-A*31: 01; HLA-B*15: 02), Japan (HLA-A*31 : 01; HLA-B*15: 11), Korea HLA-A*31: 01; HLA-B*15: 02; HLA-B*15: 11), India (HLA-B*15: 02), Thailand (HLA-B*15: 02), and Malaysia (HLA-B*15: 02). Information related to certain HLA polymorphism is important to prevent adverse drug reaction but there is no sufficient data on the population of Indonesia.

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