Open AccessKarboksimetil Kitosan Menurunkan Degranulasi Mast Cell yang Diinduksi Oleh Ovalbumin
Author(s) -
Mohamad Nur Ibrahim,
Edi Widjajanto,
Nur Permatasari,
Akhmad Sabarudin
Publication year - 2009
Publication title -
jurnal kedokteran brawijaya
Language(s) - English
Resource type - Journals
ISSN - 2338-0772
DOI - 10.21776/ub.jkb.2009.025.01.2
Subject(s) - degranulation , ovalbumin , chemistry , mast cell , compound 48/80 , allergen , immunology , allergy , biochemistry , immune system , medicine , receptor
Ovalbumin is known as mast cell degranulating agent through the FCeRI aggregation. Carboxymethyl chitosan (CMCs), a biocompatible cationic polymer was evaluated to reduces mast cell degranulation induced by ovalbumin. In this experiment, wistar rats were d arboxymethyl chitosan ivided into 5 groups which consist of 1 control group and 4 allergen groups. Among the allergen groups, 3 groups were treated with carboxymethyl chitosan/CMCs (doses : 0,25 mg, 0,50 mg and 1,00 mg) for 22 days. The result showed a significant (P<0,01) reduction in mast cell degranulation in allergen groups. This finding indicate that CMCs possesses antiinflammation activity mediated by reducing of mast cell degranulation. Keywords : ,c mast cell degranulation
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