Synthesis of Novel 3-Aryl--Methyl-1,2,5,6-Tetrahydropyridine Derivatives by Suzuki coupling: As Acetyl Cholinesterase Inhibitors | Zendy

S. Prasad | Zendy; Y.C. Sunil Kumar | Zendy; C. S. Ananda Kumar | Zendy; C. T. Sadashiva | Zendy; K. Vinaya | Zendy; Kanchugarakoppal S. Rangappa | Zendy

Open Access

Synthesis of Novel 3-Aryl--Methyl-1,2,5,6-Tetrahydropyridine Derivatives by Suzuki coupling: As Acetyl Cholinesterase Inhibitors

Author(s) -

S. Prasad,

Y.C. Sunil Kumar,

C. S. Ananda Kumar,

C. T. Sadashiva,

K. Vinaya,

Kanchugarakoppal S. Rangappa

Publication year - 2007

Publication title -

the open medicinal chemistry journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.294

H-Index - 18

ISSN - 1874-1045

DOI - 10.2174/1874104500701010004

Subject(s) - cholinesterase , aryl , suzuki reaction , chemistry , combinatorial chemistry , pharmacology , stereochemistry , organic chemistry , medicine , alkyl

Alzheimer's disease (AD) is a neurodegenerative disorder affecting the central nervous system, which is also associated with progressive loss of memory and cognition. The development of numerous structural classes of compounds with different pharmacological profile could be an evolving, promising therapeutic approach for the treatment of AD. Thus, providing a symptomatic treatment for this disease are cholinomimetics with the pharmacological profile of Acetylcholinesterase (AChE) inhibitors. In view of this, we have synthesized novel 3-aryl-N-methyl-1,2,5,6-tetrahydropyridine derivatives 5a-k by Suzuki coupling and screened the efficacy of these derivatives for their AChE inhibitor activity.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research