Integrative Physiology of Orexins and Orexin Receptors | Zendy

Michihiro Mieda | Zendy; Takeshi Sakurai | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Integrative Physiology of Orexins and Orexin Receptors

Author(s) -

Michihiro Mieda,

Takeshi Sakurai

Publication year - 2009

Publication title -

cns and neurological disorders - drug targets

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.923

H-Index - 86

eISSN - 1996-3181

pISSN - 1871-5273

DOI - 10.2174/187152709788921663

Subject(s) - narcolepsy , orexin , cataplexy , wakefulness , energy homeostasis , neuroscience , sleep (system call) , lateral hypothalamus , orexin receptor , orexin a , psychology , hypothalamus , medicine , receptor , neurology , neuropeptide , electroencephalography , computer science , operating system

Recent studies have established that the orexin system is a critical regulator of sleep/wake states. Deficiency of orexin signaling results in the sleep disorder narcolepsy-cataplexy in humans, dogs, and rodents. These findings have brought about the possibility of novel therapies for sleep disorders including narcolepsy-cataplexy. Furthermore, accumulating evidence has indicated that the orexin system regulates sleep and wakefulness through interactions with neuronal systems that regulate emotion, reward, and energy homeostasis. This review presents and discusses the current understanding of the integrative physiology of the orexin system.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research