Open AccessChromium-Picolinate Therapy in Diabetes Care: Molecular and Subcellular Profiling Revealed a Necessity for Individual Outcome Prediction, Personalised Treatment Algorithms & New Guidelines
Author(s) -
Kristina Yeghiazaryan,
Viktoriya Peeva,
Aparna Shenoy,
Hans H. Schild,
Olga Golubnitschaja
Publication year - 2011
Publication title -
infectious disorders. drug targets
Language(s) - English
Resource type - Journals
eISSN - 2212-3989
pISSN - 1871-5265
DOI - 10.2174/187152611795589717
Subject(s) - profiling (computer programming) , outcome (game theory) , chromium , computer science , algorithm , medicine , computational biology , chemistry , mathematics , biology , organic chemistry , mathematical economics , operating system
Global figures clearly demonstrate inadequacy of current diabetes care: every 10 seconds one patient dies of diabetes-related pathologies. Nephropathy is the leading secondary complication of the disease. Nutritional supplement by chromium-picolinate is assumed to have beneficial therapeutic effects. However, potential toxic effects reported increase concerns about safety of chromium-picolinate. The experimental design aimed at determining, whether the treatment with clinically relevant doses of chromium-picolinate can harm through DNA damage and extensive alterations in central detoxification / cell-cycle regulating pathways in treatment of diabetes.