Lithocholic Acid Derivative as a Model for Artificial Receptors: A Raman Study | Zendy

Fernanda M.F. Roleira | Zendy; E. J. Tavares da Silva | Zendy; Rui A. Carvalho | Zendy; M. Paula M. Marques | Zendy

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Lithocholic Acid Derivative as a Model for Artificial Receptors: A Raman Study

Author(s) -

Fernanda M.F. Roleira,

E. J. Tavares da Silva,

Rui A. Carvalho,

M. Paula M. Marques

Publication year - 2010

Publication title -

letters in drug design and discovery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.223

H-Index - 33

eISSN - 1875-628X

pISSN - 1570-1808

DOI - 10.2174/157018010792062731

Subject(s) - lithocholic acid , raman spectroscopy , chemistry , derivative (finance) , receptor , stereochemistry , biochemistry , bile acid , physics , financial economics , optics , economics

Received March 08, 2010: Revised May 14, 2010: Accepted June 01, 2010 Abstract: Two lithocholic acid (LCA) derivatives - mono- and diesters (newly synthetised) - are studied for their main conformational preferences, by Raman spectroscopy coupled to theoretical (DFT) methods. Raman bands characteristic of each compound were assigned, allowing an accurate and rapid identification of this kind of systems. The conformational preferences of the LCA diester were related with its ability to function as a model for artificial receptors, displaying a tai- lored structural profile.

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