Open AccessThe Effect of D20 on Survival of Mice with Ascites Tumor
Author(s) -
Ann Maree Hughes,
Bert M. Tolbert,
K. Lonberg-Holm,
Melvin Calvin
Publication year - 1957
Language(s) - English
Resource type - Reports
DOI - 10.2172/915075
Subject(s) - ascites , deuterium , inoculation , ehrlich ascites , tumor cells , neoplasm , toxicity , cell survival , medicine , cell division , chemistry , cancer research , cell , endocrinology , biology , immunology , pathology , biochemistry , in vitro , physics , quantum mechanics
The effect of deuterium oxide (D{sub 2}O) on the survival of mice inoculated with Ehrlich's mouse ascites tumor has been studied. Mice maintained on 25% and 30% D{sub 2}O drinking water showed an improved survival time of about 6 days whereas 40% D{sub 2}O drinking water had no effect on survival time. The effect is interpreted in terms of inhibition of tumor cell division and systemic toxicity