Open AccessEarly Detection of Melanoma and other Cancers in Residents of Nevada
Author(s) -
David C. Ward,
Nicholas J. Vogelzang
Publication year - 2006
Language(s) - English
Resource type - Reports
DOI - 10.2172/896735
Subject(s) - receiver operating characteristic , thresholding , gaussian , pattern recognition (psychology) , coincidence , false positive paradox , hermite polynomials , basis (linear algebra) , computer science , artificial intelligence , cluster analysis , basis function , volume (thermodynamics) , mathematics , statistics , physics , medicine , pathology , mathematical analysis , alternative medicine , geometry , quantum mechanics , image (mathematics)
The overall goal of this project was to develop simple and inexpensive tests to screen for the presence of early stage cancer in the residents of Nevada with a particular emphasis on the membership of the Hotel Employee Restaurant Employee International Union (HEREIU) in Las Vegas. Our specific goals were: 1) to develop a clinical database of individuals with cancer and to create a biological specimen Collection and Storage Systems (the NVCI bio-bank); 2) to initiate screening of individuals for proteomic markers indicating susceptibility to or the presence of specific cancers, e.g. breast, ovarian, prostate and bladder. In addition, we proposed the implementation of novel digital imaging technologies to detect melanoma; 3) to genotype blood samples from individuals who consent to participate in IRB approved research studies using a high throughput single nucleotide polymorphisms (SNP) method based on optical thin-film biosensor chip technology; and 4) to conduct biostatistical analysis of clinical, demographic, genetic, proteomic and digital imaging data to stratify the population cohort into relative risk groups for cancers that are prevalent in Nevada