Open AccessFinal Report on Grant DE-FG03-02ER63470
Author(s) -
John H. Miller
Publication year - 2006
Publication title -
osti oai (u.s. department of energy office of scientific and technical information)
Language(s) - English
Resource type - Reports
DOI - 10.2172/895304
Subject(s) - dna , stacking , base pair , premise , biophysics , computational biology , chemistry , pairing , biology , physics , biochemistry , philosophy , linguistics , superconductivity , organic chemistry , quantum mechanics
The goal of this project is to provide critical information to characterize the qualitative and quantitative similarities and difference in repair characteristics between clustered damage sites formed by ionizing radiation and singly damaged sites produced by endogenous processes. The premise is that base pairing and base stacking interactions are qualitatively and quantitatively different for singly and multiply damaged DNA sites. State-of-the-art computational chemistry model were used to characterize the structure, energetics, and spectroscopy of singly and multiply damaged (clustered) DNA sites
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