Open AccessMolecular Recognition of DNA Damage Sites by Apurinic/Apyrimidinic Endonucleases
Author(s) -
Werner Braun
Publication year - 2005
Publication title -
osti oai (u.s. department of energy office of scientific and technical information)
Language(s) - English
Resource type - Reports
DOI - 10.2172/877152
Subject(s) - ap site , dna (apurinic or apyrimidinic site) lyase , endonuclease , dna repair , dna damage , dna , ap endonuclease , xrcc1 , biology , microbiology and biotechnology , chemistry , computational biology , genetics , gene , genotype , single nucleotide polymorphism
The DNA repair/redox factor AP endonuclease 1 (APE1) is a multifunctional protein which is known to to be essential for DNA repair activity in human cells. Structural/functional analyses of the APE activity is thus been an important research field to assess cellular defense mechanisms against ionizing radiation
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