Interim report on intrathoracic radiotherapy of human small-cell lung carcinoma in nude mice with Re-188-RC-160, a radiolabeled somatostatin analogue | Zendy

Paul O. Zamora | Zendy; H. Bender | Zendy; H. J. Biersack | Zendy; Furn F. Knapp | Zendy

Open Access

Interim report on intrathoracic radiotherapy of human small-cell lung carcinoma in nude mice with Re-188-RC-160, a radiolabeled somatostatin analogue

Author(s) -

Paul O. Zamora,

H. Bender,

H. J. Biersack,

Furn F. Knapp

Publication year - 1995

Publication title -

osti oai (u.s. department of energy office of scientific and technical information)

Language(s) - English

Resource type - Reports

DOI - 10.2172/87003

Subject(s) - somatostatin , small cell lung carcinoma , lung , biodistribution , carcinoma , pathology , medicine , cell , cell culture , thoracic cavity , cancer research , pleural cavity , small cell carcinoma , oncology , chemistry , biology , in vivo , anatomy , genetics , microbiology and biotechnology , biochemistry

The purpose of this study was to evaluate the therapeutic efficacy of Re-188-RC-160 in experimental models of human small cell lung carcinomas which mimic the clinical presentation. In the experimental model, cells from the human small cell lung carcinoma cell line NCI-H69 cells were inoculated into the thoracic cavity of athymic mice and rats. Subsequently, the biodistribution of Re-188-RC-160 after injection into the pleural cavity, a radiolabeled somatostatin analogue, was monitored as was the effect on the subsequent growth of tumors. The results presented here, and which are a part of a larger series of studies, suggest that Re-188-RC-160 can be effectively used in this animal model to restrict the growth of small cell lung carcinoma in the thoracic cavity

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