Genomic Sequence Comparisons, 1987-2003 Final Report | Zendy

George M. Church | Zendy

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Genomic Sequence Comparisons, 1987-2003 Final Report

Author(s) -

George M. Church

Publication year - 2004

Publication title -

osti oai (u.s. department of energy office of scientific and technical information)

Language(s) - English

Resource type - Reports

DOI - 10.2172/827024

Subject(s) - dna sequencing , genome , multiplex , genome project , whole genome sequencing , computational biology , biology , cancer genome sequencing , sequence (biology) , personal genomics , reference genome , sequence assembly , genetics , annotation , gene , gene expression , transcriptome

This project was to develop new DNA sequencing and RNA and protein quantitation methods and related genome annotation tools. The project began in 1987 with the development of multiplex sequencing (published in Science in 1988), and one of the first automated sequencing methods. This lead to the first commercial genome sequence in 1994 and to the establishment of the main commercial participants (GTC then Agencourt) in the public DOE/NIH genome project. In collaboration with GTC we contributed to one of the first complete DOE genome sequences, in 1997, that of Methanobacterium thermoautotropicum, a species of great relevance to energy-rich gas production

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