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This paper describes the statistical issues involved in analyzing data from high-energy gamma-ray telescopes, at levels from event reconstruction to correlations of populations of astrophysical sources. Some motivation for attempting to do astronomy with high-energy gamma rays is also given, along with some of the constraints implied by operating the instrument in orbit. Specific attention is given to the Large Area Telescope (LAT) under development for launch in late 2006 on the Gamma-ray Large Area Space Telescope (GLAST) mission.

Statistical Issues in High-Energy Gamma-Ray Astronomy for GLAST